Nanditha was born in Mumbai. Her father, Col Raj Kumar is an Army officer and mother Vasthi Raj is a legal advisor. She has a younger brother named Prateek. She grew up in North India  and has studied in Army schools. She currently resides in Hyderabad and is pursuing her degree from St Francis College for Women, Hyderabad.

She had not planned a career in films but her mother encouraged her to participate in a beauty contest which she won. In her first year of college, she sent her photographs to director Teja and was called for an audition

London Bridge is a Malayalam film directed by Anil C. Menon starring Prithviraj Sukumaran, Mukesh, Andrea Jeremiah and Nanditha Raj in the lead roles. The film penned by Jinu Abraham was entirely shot in the United Kingdom. Rahul Raj composed three original songs and left the project owing to scheduling conflicts. Thus Carnatic vocalist Dr. Sreevalsan Menon was hired to compose two additional songs and Gopi Sundar was signed in to compose the background score. The film is produced by Antony Binoy and Sathish B under the banner Ordinary Pictures.